Describe the Krebs cycle.

Vedclass pdf generator app on play store
Vedclass iOS app on app store
(N/A) The $TCA$ cycle starts with the condensation of an acetyl group with oxaloacetic acid $(OAA)$ and water to yield citric acid. The reaction is catalyzed by the enzyme citrate synthase, and a molecule of $CoA$ is released.
$OAA (4C) + \text{Acetyl } CoA + H_2O (2C) \xrightarrow{\text{Citrate synthase}} \text{Citric acid } (6C) + CoA$
Citrate is then isomerized to isocitrate.
It is followed by two successive steps of decarboxylation, leading to the formation of $\alpha$-ketoglutaric acid and then succinyl-$CoA$.
$\text{Citric acid} \rightarrow \text{Isocitrate} \rightarrow \alpha\text{-ketoglutaric acid}$
Remaining steps of the citric acid cycle:
Succinyl-$CoA$ is oxidized to $OAA$, allowing the cycle to continue.
During the conversion of succinyl-$CoA$ to succinic acid, a molecule of $GTP$ is synthesized. This is a substrate-level phosphorylation.
In a coupled reaction, $GTP$ is converted to $GDP$ with the simultaneous synthesis of $ATP$ from $ADP$.
$GTP \rightarrow GDP + Pi \rightarrow ADP + Pi \rightarrow ATP$
Also, there are three points in the cycle where $NAD^+$ is reduced to $NADH + H^+$ and one point where $FAD^+$ is reduced to $FADH_2$. The continued oxidation of acetyl $CoA$ via the $TCA$ cycle requires the continued replenishment of oxaloacetic acid.
It is the first member of the cycle. In addition, it also requires the regeneration of $NAD^+$ and $FAD^+$ from $NADH$ and $FADH_2$, respectively.
The summary equation for this phase of respiration may be written as follows:
$\text{Pyruvic acid} + 4NAD^+ + FAD^+ + 2H_2O + ADP + Pi \xrightarrow{\text{Mitochondrial Matrix}} 3CO_2 + 4NADH + 4H^+ + FADH_2 + ATP$
Glucose has been broken down to release $CO_2$, and eight molecules of $NADH + H^+$; two of $FADH_2$ have been synthesized besides just two molecules of $ATP$ in the $TCA$ cycle.

Explore More

Similar Questions

Which of the following is produced during Kreb's cycle?

The number of steps required for the complete oxidation of one molecule of pyruvic acid in the Krebs cycle is

In aerobic respiration,the citric acid cycle takes place in:

Which enzyme is associated with the oxidative phosphorylation process in the $Kreb's$ cycle?

During the Krebs cycle,the intermediate $\alpha$-ketoglutarate is formed as a result of . . . . . . .

Vedclass Products

For Students

Vedclass Test Series

Mock tests in real JEE/NEET style with performance analysis. 5-day free trial.

Start Free Trial
For Teachers

Exam Paper Generator

Generate Set A/B/C/D exam papers from 7.5L+ questions in 2 minutes. 3 chapters free.

Try Free
For Institutes

Online Exam Module

Live online exams with unlimited students, 360° analytics & white-label branding.

See Demo