The reaction shown below is an example of Nuc | vedclass

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Question

(A) In Nucleophilic Aromatic Substitution $(S_NAr)$ reactions,the rate-determining step is the attack of the nucleophile on the aromatic ring to form

Vedclass · Accepted Answer

$-F$

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(A) In Nucleophilic Aromatic Substitution $(S_NAr)$ reactions,the rate-determining step is the attack of the nucleophile on the aromatic ring to form a Meisenheimer complex. In this specific mechanism,the electronegativity of the halogen atom plays a crucial role. Since the fluorine atom is the most electronegative,it exerts the strongest $-I$ (inductive) effect,which significantly stabilizes the transition state (the carbanion intermediate) by withdrawing electron density from the ring. Therefore,the reactivity order for nucleophilic aromatic substitution is $F > Cl > Br > I$. Thus,the $-F$ atom is the most readily replaced.

The reaction shown below is an example of Nucleophilic Aromatic Substitution. Which of the following halides $(-X)$ is most readily replaced?

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