How are prosthetic groups different from co-f | vedclass

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(B) Co-factors are non-protein components that bind to an apoenzyme to make the enzyme catalytically active. They are classified into three types: pro

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Prosthetic groups are tightly bound to the apoenzyme,whereas other co-factors may be loosely bound.

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(B) Co-factors are non-protein components that bind to an apoenzyme to make the enzyme catalytically active. They are classified into three types: prosthetic groups,co-enzymes,and metal ions.$1$. Prosthetic groups are organic compounds that are tightly or strongly bound to the apoenzyme (e.g.,heme in peroxidase and catalase).$2$. Co-enzymes are organic compounds that associate with the apoenzyme only during the course of catalysis and are usually loosely bound (e.g.,$NAD$ and $NADP$).$3$. Metal ions form coordination bonds with side chains at the active site and also form one or more coordination bonds with the substrate (e.g.,$Zn^{2+}$ in carboxypeptidase).Thus,the primary difference is that prosthetic groups are permanently and strongly attached to the apoenzyme,whereas other co-factors (like co-enzymes) are often loosely associated.

How are prosthetic groups different from co-factors?

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